Jackline De Paula Ayres-Silva | radiation | Women Researcher Award

Dr. Jackline De Paula Ayres-Silva | radiation | Women Researcher Award

Senior Researcher at Oswaldo Cruz Foundation, Brazil

Dr. Jackline de Paula Ayres-Silva is a dedicated researcher with expertise in hematopoiesis, oncology, and molecular biology, with training from leading institutions in Brazil and international research experience at the Mayo Clinic. Her work integrates classical molecular techniques with advanced genomic approaches, including array-CGH and whole exome sequencing, to investigate hematological malignancies and the progression of myeloproliferative neoplasms to acute leukemia. She has contributed to high-impact publications, mentored undergraduate students, and secured research grants, highlighting her leadership and commitment to advancing science. Her research spans diverse models such as mice, zebrafish, and human clinical studies, reflecting versatility and translational relevance. Recognized with several honors for outstanding scientific contributions and mentoring, she continues to strengthen her profile as both an independent investigator and collaborator in multidisciplinary teams. Dr. Ayres-Silva’s career demonstrates a balance of technical expertise, innovative research, and dedication to fostering future scientists.

Professional Profile 

Google Scholar | Scopus Profile | ORCID Profile 

Education

Dr. Jackline de Paula Ayres-Silva built a strong academic foundation through rigorous training in the biological and biomedical sciences. She earned her undergraduate degree in Biology/Genetics and went on to complete a master’s degree in Morphology, followed by a doctorate in Oncology at the National Cancer Institute in Brazil. Her academic journey included early research experiences as a scholarship recipient during her undergraduate studies and advanced training fellowships at prominent institutions, including the Mayo Clinic in the United States. These opportunities enabled her to gain exposure to diverse research methodologies, from traditional molecular biology techniques to state-of-the-art genomic approaches. Alongside her formal academic milestones, she pursued additional specialized training in histopathology, genomics, and cancer biology, equipping her with both theoretical knowledge and practical skills. This well-rounded education provided the necessary platform for her future contributions to cancer research, hematopoiesis, and molecular medicine.

Experience

Dr. Jackline de Paula Ayres-Silva has extensive research and professional experience across multiple scientific domains. Early in her career, she worked in the Anatomic Pathology Division at the Brazilian National Cancer Institute, where she assisted with histopathological diagnostics and research support. Her experience broadened internationally during a fellowship at the Mayo Clinic, where she was trained in advanced genomic methodologies under expert mentorship. Throughout her career, she has conducted research on both normal and pathological hematopoiesis using diverse models, including mice, zebrafish, and human patient samples. She has applied techniques ranging from PCR and immunohistochemistry to next-generation sequencing, enabling her to explore the genetic and molecular underpinnings of blood disorders and cancer progression. Beyond laboratory work, she has taken on roles as a mentor, guiding undergraduate students in research projects and fostering their academic growth. Her career demonstrates a balance of hands-on research expertise, academic mentorship, and international collaboration.

Research Focus

Dr. Jackline de Paula Ayres-Silva’s research is centered on understanding hematological malignancies, hematopoietic development, and the genetic mechanisms underlying disease progression. Her primary focus has been on myeloproliferative neoplasms and their evolution into acute leukemia, where she has contributed significantly to molecular diagnostics and monitoring. She has implemented and applied molecular assays for key mutations, including JAK2 and CALR, and worked on identifying genetic alterations linked to disease progression. Her research also extends to fetal hematopoietic development, exploring how the extracellular matrix and microenvironments influence blood cell formation. By integrating traditional pathology methods with high-throughput genomic tools such as whole exome sequencing and array-CGH, she has advanced knowledge in both basic and translational science. Additionally, her collaborative projects span chronic lymphocytic leukemia and central nervous system lymphomas, reflecting a broad interest in cancer genetics. Her ongoing work aims to model genetic alterations in vivo, further bridging laboratory discoveries with clinical relevance.

Award and Honor

Dr. Jackline de Paula Ayres-Silva has been recognized with several awards and honors that highlight her contributions to science, research mentorship, and academic excellence. Early in her career, she was acknowledged for her presentations at scientific congresses, being ranked among the top trainees at Fiocruz and receiving recognition for excellence in international symposiums on stem cell transplantation. Her achievements continued with distinctions such as best and third-best presentations at prestigious scientific meetings, reflecting both the quality and impact of her work. More recently, she received honorable mentions at the Annual Congress on Undergraduate Degree Fellowships organized by the Oswaldo Cruz Foundation, acknowledging her role in research mentorship and guidance. These honors not only demonstrate her capacity to produce significant scientific findings but also underline her dedication to fostering the next generation of researchers. Collectively, her awards validate her position as an accomplished and influential scientist in her field.

Publication Top Notes

  • Title: Genome-wide analysis uncovers novel recurrent alterations in primary central nervous system lymphomas
    Authors: E. Braggio, S. Van Wier, J. Ojha, E. McPhail, Y.W. Asmann, J. Egan, J. Ayres-Silva, …
    Year: 2015
    Citations: 241

  • Title: Deep sequencing identifies genetic heterogeneity and recurrent convergent evolution in chronic lymphocytic leukemia
    Authors: J. Ojha, J. Ayres, C. Secreto, R. Tschumper, K. Rabe, D. Van Dyke, S. Slager, …
    Year: 2015
    Citations: 77

  • Title: Monoclonal B-cell lymphocytosis is characterized by mutations in CLL putative driver genes and clonal heterogeneity many years before disease progression
    Authors: J. Ojha, C. Secreto, K. Rabe, J. Ayres-Silva, R. Tschumper, D.V. Dyke, …
    Year: 2014
    Citations: 59

  • Title: Sequential morphological characteristics of murine fetal liver hematopoietic microenvironment in Swiss Webster mice
    Authors: J. de Paula Ayres-Silva, P.P. de Abreu Manso, M.R. da Cunha Madeira, …
    Year: 2011
    Citations: 51

  • Title: Global profile of anemia during pregnancy versus country income overview: 19 years estimative (2000–2019)
    Authors: E. Araujo Costa, J. de Paula Ayres-Silva
    Year: 2023
    Citations: 44

  • Title: Increased expression of tissue factor and protease-activated receptor-1 does not correlate with thrombosis in human lung adenocarcinoma
    Authors: E. De Meis, D. Azambuja, J.P. Ayres-Silva, M. Zamboni, V.R. Pinheiro, …
    Year: 2010
    Citations: 34

  • Title: Lymphatic vessels in human adipose tissue
    Authors: P.A.G. Redondo, F. Gubert, C. Zaverucha-do-Valle, T.P.P. Dutra, J. Ayres-Silva, …
    Year: 2020
    Citations: 26

  • Title: Hydroxyurea dose impacts hematologic parameters in polycythemia vera and essential thrombocythemia but does not appreciably affect JAK2-V617F allele burden
    Authors: I.R. Zalcberg, J. Ayres-Silva, A.M. de Azevedo, C. Solza, A. Daumas, …
    Year: 2011
    Citations: 17

  • Title: Genetic alterations in essential thrombocythemia progression to acute myeloid leukemia: a case series and review of the literature
    Authors: J.P. Ayres-Silva, M.H. Bonamino, M.E. Gouveia, B.C.R. Monte-Mor, …
    Year: 2018
    Citations: 12

  • Title: Clinical features of JAK2V617F- or CALR-mutated essential thrombocythemia and primary myelofibrosis
    Authors: Z.I. Monte-Mor Bda C, J. de Paula Ayres-Silva, W.D. Correia, A.C. Coelho, C. Solza, …
    Year: 2016
    Citations: 12

  • Title: Oral Trypanosoma cruzi Acute Infection in Mice Targets Primary Lymphoid Organs and Triggers Extramedullary Hematopoiesis
    Authors: A. Marins-Dos-Santos, J.P. Ayres-Silva, D. Antunes, C.J.C. Moreira, …
    Year: 2022
    Citations: 6

  • Title: JAK2 V617F allele burden quantified by real time quantitative polymerase chain reaction and competitive polymerase chain reaction in patients with chronic myeloproliferative neoplasia
    Authors: J. Kaeda, M. Bonamino, J. Ayres-Silva, C. Solza, F. Ringel, O. Blau, …
    Year: 2014
    Citations: 4

  • Title: Lectin-based carbohydrate profile of megakaryocytes in murine fetal liver during development
    Authors: B.C.M. Bomfim, J. Azevedo-Silva, G. Caminha, J.P.R. Santos, J. de Paula Ayres-Silva, …
    Year: 2023
    Citations: 3

  • Title: Animal welfare in radiation research: the importance of animal monitoring system
    Authors: M.R. Lima, D.C.P. Campbell, M.R. Cunha-Madeira, B.C.M. Bomfim, J. de Paula Ayres-Silva, …
    Year: 2023
    Citations: 2

  • Title: The genomic landscape of primary central nervous system lymphomas
    Authors: E. Braggio, B.P. O’Neill, S. Van Wier, J. Ojha, J. Ayres-Silva, R. Valdez, J. Egan, …
    Year: 2013
    Citations: 2

Conclusion

Dr. Jackline de Paula Ayres-Silva has established a solid body of research that spans hematology, oncology, molecular biology, and developmental biology, with impactful contributions recognized through both publications and citations. Her works range from fundamental studies on hematopoietic development to translational research on hematological malignancies, with particular emphasis on myeloproliferative neoplasms, leukemia, and cancer genomics. Several of her publications have been widely cited, underscoring their scientific influence and relevance in the research community. Beyond advancing knowledge, her collaborations with international institutions and contributions to multidisciplinary projects highlight her ability to work across diverse scientific environments. The combination of highly cited research, continuous output in peer-reviewed journals, and recognition in scientific forums positions her as a researcher of significant merit. Overall, Dr. Ayres-Silva demonstrates the expertise, innovation, and leadership qualities that strongly support her suitability for recognition such as the Best Researcher Award.

Krzysztof Jeziorski | Oncology | Best Researcher Award

Dr. Krzysztof Jeziorski | Oncology | Best Researcher Award 

Department of Gerontology and Public Health at National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland

Dr. Krzysztof Grzegorz Jeziorski, MD, PhD, is a distinguished Polish oncologist with a career spanning over four decades in clinical and academic medicine. He has served as Associate Professor and Senior Assistant at the Maria Skłodowska-Curie National Research Cancer Institute in Warsaw since 1988 and continues to contribute as a Clinical Trials Consultant at the National Institute of Geriatrics, Rheumatology and Rehabilitation. Dr. Jeziorski’s professional path is marked by leadership in gastrointestinal cancer research, extensive clinical trial involvement, and international academic collaborations. A former Dean of the Faculty of Health Sciences and Social Sciences, he combines deep clinical expertise with academic excellence. He has participated in fellowships across Europe, including at the University of Oxford and the University of Padova. Renowned for his commitment to advancing cancer research, he continues to enhance his knowledge through postgraduate studies and remains actively engaged in both practice and education.

Professional Profile 

Scopus Profile
ORCID Profile 

Education

Dr. Jeziorski earned his medical degree from the Medical University of Warsaw, completing the I Medical Faculty. He later pursued advanced specialization, obtaining first and second-grade specialties in General Medicine and Chemotherapy of Cancer from the Medical Centre of Postgraduate Education. His passion for oncology led him to further achieve a specialty in Clinical Oncology and a Doctorate in Medical Sciences. In 2009, he was awarded the prestigious Habilitation degree from the Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology. Dr. Jeziorski has continually enriched his education through prestigious fellowships and academic programs, including at the Universities of Oxford, Padova, Brussels, and Cambridge. He completed several key international training programs in epidemiology and public health. Recently, he completed postgraduate studies in Clinical Trial Methodology and is currently pursuing an MBA in Clinical Research and Biomedical Innovation Management at the Medical University of Warsaw, demonstrating his continued commitment to academic and professional growth.

Experience

Dr. Jeziorski brings a wealth of experience from clinical, academic, and administrative roles. Since 1988, he has been a leading figure at the Maria Skłodowska-Curie National Research Cancer Institute in Warsaw, serving as Associate Professor and senior assistant in the Outpatient Department for GI Cancers. He has also been a Clinical Trials Consultant at the National Institute of Geriatrics, Rheumatology and Rehabilitation since 2015. Earlier in his career, he worked with institutions like the Polish Academy of Sciences and served as Dean at the State Higher School of Pope John Paul II in Biała Podlaska. His clinical foundation was established at the Central Hospital of the Medical Academy in Warsaw. Dr. Jeziorski has managed over 20 international clinical trials as a Principal Investigator, contributing significantly to cancer research. His experience integrates scientific leadership, teaching, and hands-on patient care, making him a well-rounded and respected professional in medical oncology and research.

Awards and Honors

While a detailed list of awards is not provided in the curriculum vitae, Dr. Jeziorski’s academic journey includes several significant milestones that reflect a career of distinction. He received his Second Grade Specialty in Chemotherapy of Cancer with distinction, signaling outstanding academic and clinical performance. His international fellowships at elite institutions such as the University of Oxford, University of Padova, and University of Cambridge were awarded on a competitive basis and recognize his academic merit and research potential. Additionally, his long-term appointments at top-tier research institutes and his role as a Dean suggest institutional recognition of his expertise and leadership. Acceptance into high-profile postgraduate and international research training programs—including the Erasmus Summer Program and WHO/IDF seminars—further highlight his professional standing. His ongoing pursuit of an MBA in Clinical Research reflects both personal ambition and recognition of his evolving role in biomedical innovation and management.

Research Focus on Oncology

Dr. Jeziorski’s primary research focus lies in the field of gastrointestinal oncology, where he has made sustained contributions through clinical trials and academic leadership. He has acted as Principal Investigator in over 20 international clinical trials and participated in numerous additional studies as a Sub-Investigator. His research emphasizes improving therapeutic strategies for gastrointestinal neoplasms, with a strong interest in translating scientific findings into clinical practice. Dr. Jeziorski combines rigorous methodological training with deep clinical insight, as demonstrated by his postgraduate studies in clinical trial methodology and his continued education in research management. His international fellowships enriched his approach to evidence-based medicine and interdisciplinary collaboration. Throughout his career, he has actively worked to integrate public health perspectives and epidemiology into oncology research. By maintaining roles in both clinical care and research, Dr. Jeziorski ensures his work remains patient-centered, innovative, and aligned with global advances in cancer treatment.

Publications Top Notes

  • Title: Artificial Intelligence in Oncology

    • Authors: Krzysztof Jeziorski, Robert Olszewski

    • Year: 2024

  • Title: Lost in Communication: Do Family Physicians Provide Patients with Information on Preventing Diet-Related Diseases?

    • Authors: Robert Olszewski, Justyna Obiała, Karolina Obiała, Jakub Owoc, Małgorzata Mańczak, Klaudia Ćwiklińska, Magdalena Jabłońska, Paweł Zegarow, Jolanta Grygielska, Marzena Jaciubek, et al.

    • Year: 2022

  • Title: Hyperthermia in Rheumatic Diseases. A Promising Approach?

    • Author: Krzysztof Jeziorski

    • Year: 2018

  • Title: HER2 Status in GI Adenocarcinoma (TRIO-013/LOGiC Trial)

    • Authors: Press M.F., Ellis C.E., Gagnon R.C., Jeziorski K., et al.

    • Year: 2017

  • Title: Preservation of Duodenal Passage and Quality of Life After Gastrectomy

    • Authors: Olesiński T., Szpakowski M., Saramak P., Rutkowski A., Jeziorski K.

    • Year: 2017

  • Title: Rheumatic and Oncological Diseases – Common Challenges

    • Author: Krzysztof Jeziorski

    • Year: 2017

  • Title: Lapatinib + Chemotherapy in HER2+ GI Cancers (LOGiC Trial)

    • Authors: Hecht J.R., Bang Y.-J., Qin S.K., Jeziorski K., et al.

    • Year: 2016

  • Title: Preoperative Chemoradiation vs Short-Course Therapy in Rectal Cancer

    • Authors: Bujko K., Wyrwicz L., Rutkowski A., Jeziorski K., et al.

    • Year: 2016

  • Title: Validation of QLQ-GINET21 for GI Neuroendocrine Tumors

    • Authors: Yadegarfar G., Friend L., Jeziorski K., et al.

    • Year: 2013

  • Title: Efficacy of Y-90 DOTATATE in GEP-NETs – Phase II Study

    • Authors: Cwikla J.B., Sankowski A., Jeziorski K.G., et al.

    • Year: 2009

  • Title: Radiological Efficacy of 90Y-DOTATATE in Midgut NETs

    • Authors: Cwikla J.B., Sankowski A., Jeziorski K.G., et al.

    • Year: 2009

  • Title: Abscesses After Splenectomy in Gastric/Cardia Cancer Surgery

    • Authors: Szpakowski M., Olesiński T., Jeziorski K., et al.

    • Year: 2007

  • Title: Chemotherapy for Hepatocellular and Biliary Duct Cancers

    • Author: Krzysztof Jeziorski

    • Year: 2007

  • Title: Imaging of Gastroenteropancreatic NETs – Polish Center Experience

    • Authors: Cwikla J.B., Nasierowska-Guttmejer A., Jeziorski K.G., et al.

    • Year: 2007

  • Title: Leptomeningeal Metastases of EGJ Adenocarcinoma – Case Report

    • Authors: Olesiński T., Jeziorski K., Szawłowski A.

    • Year: 2007

Conclusion

Dr. Krzysztof Jeziorski exemplifies a distinguished researcher and clinician whose contributions to gastrointestinal oncology span over four decades. His involvement in high-impact, multi-center clinical trials, coupled with authorship in internationally recognized journals such as Journal of Clinical Oncology, Annals of Oncology, and British Journal of Cancer, highlights both the breadth and relevance of his work. He has consistently collaborated with global experts and participated in pivotal studies that influence cancer treatment protocols. His recent engagement with artificial intelligence in oncology indicates a forward-thinking and adaptive research approach. Although citation metrics for many of his publications are not readily available, the scope, continuity, and quality of his work speak to his lasting impact on cancer research. Dr. Jeziorski’s blend of clinical excellence, academic leadership, and international collaboration positions him as a highly deserving candidate for the Best Researcher Award, with a legacy that bridges science, innovation, and patient-centered care.