Hans-Werner Denker | Medicine and Dentistry | Best Researcher Award

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Prof. Dr. Hans-Werner Denker | Medicine and Dentistry | Best Researcher Award

University Professor at Universität Duisburg-Essen, Germany

Prof. Dr. Hans-Werner Denker is a distinguished scientist whose pioneering work has significantly advanced the fields of developmental biology, reproductive biology, and stem cell research. His studies have provided deep insights into embryonic development, cell differentiation, trophoblast-endometrial interactions, and implantation biology, establishing him as a leading authority in reproductive sciences. He has also contributed extensively to stem cell biology, focusing on pluripotency, embryoid formation, and the ethical dimensions of stem cell research, which has global scientific and societal importance. As Head of Anatomy and Developmental Biology at a major university, he demonstrated exceptional leadership, mentoring, and academic vision. His editorial stewardship of an international journal for more than two decades further highlights his influence in shaping scientific discourse worldwide. Through interdisciplinary collaborations and innovative approaches, including the use of 3D model systems, Prof. Denker has left a lasting impact, making him a highly respected and influential figure in biomedical research.

Professional Profile 

Scopus Profile | ORCID Profile 

Education

Prof. Dr. Hans-Werner Denker pursued a comprehensive academic path that combined medicine and zoology, laying a strong interdisciplinary foundation for his career. He studied medicine at the University of Hamburg and the University of Marburg, completing his medical state examination and licensure, followed by his M.D. with a dissertation on enzymatic topochemistry during early rabbit embryonic development. Simultaneously, he studied zoology at the University of Marburg, earning a Ph.D. focused on carbohydrate chemistry in early implantation processes. This dual training in both medicine and natural sciences provided him with a unique perspective on developmental biology and reproductive sciences. In 1976, he achieved his Habilitation at RWTH Aachen University, gaining the venia legendi in anatomy and reproductive biology, which marked the formal recognition of his ability to independently conduct advanced research and teaching. His diverse academic background equipped him with the tools to address complex biological questions at multiple levels.

Experience

Prof. Dr. Hans-Werner Denker’s professional journey reflects decades of excellence in academic leadership, research, and international collaboration. He began his career as a scientific assistant and later senior assistant at the Max Planck Institute for Immunobiology in Freiburg. His international outlook was shaped by visiting scientist roles in the United States, including Wayne State University in Detroit and the University of California at Davis. He subsequently served as Assistant Professor and later full Professor at RWTH Aachen University, where he headed the Division of Anatomy and Reproductive Biology. In 1989, he was appointed Chair and Head of the Institute of Anatomy at the University of Duisburg-Essen, a position he held until his retirement. Throughout his career, he guided both research and education, establishing new directions in anatomy, developmental biology, and reproductive sciences. His leadership extended beyond institutions to the broader scientific community, shaping research agendas at the international level.

Research Focus

Prof. Dr. Hans-Werner Denker’s research spans developmental biology, reproductive biology, and stem cell science, with an emphasis on the earliest stages of mammalian life. He investigated the processes of cleavage, blastocyst formation, and cell differentiation, particularly focusing on trophoblast and embryoblast development. His pioneering work in embryo implantation examined cell-cell and cell-matrix interactions, epithelial-mesenchymal transitions, and the role of adhesion molecules and proteinases. He developed innovative model systems, such as 3D trophoblast spheroids and endometrial cultures, which became valuable tools for studying implantation and tumor invasion. In stem cell biology, he explored pluripotency, totipotency, embryoid formation, and ethical questions surrounding stem cell research. His studies bridged fundamental biology with applied biomedical challenges, providing insights relevant to infertility, regenerative medicine, and cancer biology. By integrating developmental biology with bioethics, he addressed not only scientific but also societal implications, making his research influential across multiple domains.

Award and Honor

Prof. Dr. Hans-Werner Denker has earned wide recognition for his lifelong contributions to science, academia, and ethical discourse in biology. While his most visible honor is his long tenure as Editor-in-Chief of the prestigious international journal Acta Anatomica (later Cells Tissues Organs), where he influenced global scholarship for over two decades, his reputation is equally reflected in memberships across leading scientific societies. He has been an active member of organizations such as the Society for the Study of Reproduction, the German Society for Cell Biology, and the European Tissue Engineering Society. His expertise was sought in interdisciplinary networks like the Competence Network for Stem Cell Research in North Rhine-Westphalia, underscoring his role in advancing both research and policy. Although specific awards are not detailed in the provided record, his leadership roles, editorship, and international collaborations serve as strong evidence of the recognition and respect he has earned within the scientific community.

Publication Top Notes

  • Title: Embryoids, models, embryos? We need to take a new look at legal norms concerning the beginning of organismic development
    Authors: Hans-Werner Denker
    Year: 2023
    Citations: 3

  • Title: Stem Cell-Derived Organoids, Embryoids, and Embryos: Advances in Organismic Development In Vitro Force Us to Re-Focus on Ethical and Legal Aspects of Model Choice
    Authors: Hans-Werner Denker
    Year: 2023

  • Title: Autonomy in the Development of Stem Cell-Derived Embryoids: Sprouting Blastocyst-Like Cysts, and Ethical Implications
    Authors: Hans-Werner Denker
    Year: 2021
    Citations: 17

Conclusion

In conclusion, Prof. Dr. Hans-Werner Denker’s publications highlight a career deeply committed to advancing developmental biology, reproductive science, and stem cell research, while simultaneously addressing the ethical and legal implications of these fields. His recent works on embryoids, organoids, and embryonic self-organization underscore both his scientific depth and his engagement with societal concerns. With strong citation impact and international recognition, his research continues to influence scientific understanding, ethical debates, and biomedical policy. Overall, his body of work demonstrates the qualities of a visionary researcher whose contributions extend far beyond laboratory findings, making him an exemplary candidate for recognition and awards in research excellence.

Laura Garriga-Grimau | Medicine and Dentistry | Best Researcher Award

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Dr. Laura Garriga-Grimau | Medicine and Dentistry | Best Researcher Award

Physician at Hospital Universitari Vall d’Hebron, Spain

Dr. Laura Garriga-Grimau is a dedicated pediatric pulmonologist based at Vall d’Hebron University Hospital in Barcelona, Spain. She specializes in bronchiectasis, cystic fibrosis, and other chronic pediatric lung conditions. Her work bridges clinical practice, academic research, and teaching. She is actively involved in multiple international research collaborations, including the European Respiratory Society (ERS) and the Child-BEAR-Net Registry. A strong advocate for improving respiratory care in children, Dr. Garriga-Grimau has authored numerous peer-reviewed publications and contributed to global studies shaping pediatric lung health guidelines. Her academic and clinical background is enriched by international clinical training in Australia and active teaching roles at the Autonomous University of Barcelona. Known for her collaborative leadership and deep scientific insight, she continues to contribute to innovation in pediatric respiratory medicine while mentoring future healthcare professionals. Her work is both evidence-driven and patient-centered, earning her a growing reputation in European and global pediatric research communities.

🔹 Professional Profile 

Scopus Profile
ORCID Profile 

🏆Strengths for the Award

Dr. Laura Garriga-Grimau has demonstrated a strong commitment to advancing pediatric respiratory medicine through a blend of clinical excellence, academic research, and international collaboration. Her specialization in bronchiectasis and cystic fibrosis has positioned her as a key contributor in areas that are often underrepresented in pediatric research. She currently holds leadership roles in prominent research initiatives, such as Chair of the ERS Task Force on Transitioning Adolescents with Bronchiectasis, and Deputy Co-Chair of the Child-BEAR-Net Registry, reflecting the recognition she commands within global respiratory research communities. These roles not only highlight her scientific insight but also her ability to coordinate multinational teams and influence clinical policy development.

Her publication record is both prolific and impactful, including research in The Lancet Respiratory Medicine, New England Journal of Medicine, and other peer-reviewed international journals. Dr. Garriga-Grimau has contributed to high-quality, multi-center studies and registries that address real-world challenges in diagnosis, treatment, and care models for pediatric lung diseases. Notably, her involvement in the SHIP-CT trial and the Spanish Pediatric Bronchiectasis Registry demonstrates her ability to participate in and lead complex clinical research initiatives with both academic and translational value. Her research outputs are data-driven, well-cited, and directly relevant to improving health outcomes in children globally.

In addition to her research achievements, Dr. Garriga-Grimau has actively bridged the gap between academia and clinical practice. She contributes as a faculty member in the Pediatric Pulmonology Master’s program at the Autonomous University of Barcelona and has been involved in mentoring and training future clinicians and researchers. Her international clinical exposure, including a bronchiectasis fellowship in Australia, enhances the global relevance and cultural sensitivity of her work. This combination of academic productivity, clinical innovation, and leadership in international research networks makes her a well-rounded and highly deserving candidate for the Best Researcher Award.

🎓Education

Dr. Laura Garriga-Grimau completed her medical education and pediatric residency through the Spanish MIR system at the University of Barcelona, one of Spain’s leading academic medical centers. Following her pediatric training, she pursued specialized academic advancement through a Master’s degree in Pediatric Pulmonology from the Autonomous University of Barcelona (UAB), where she later became a faculty member. Her passion for research and respiratory medicine led her to complete a PhD focused on cystic fibrosis at Vall d’Hebron University Hospital, contributing significant findings to the field. In addition to her formal education, Dr. Garriga-Grimau enriched her academic and clinical knowledge with a training fellowship in bronchiectasis at the Queensland Children’s Hospital in Australia. Her continuous pursuit of learning, from clinical practice to translational research, has equipped her with a strong foundation in evidence-based medicine and multidisciplinary collaboration, shaping her into a leader in pediatric respiratory care both in Spain and internationally.

💼 Experience

Dr. Laura Garriga-Grimau has built an extensive and dynamic professional career in pediatric pulmonology, anchored at Vall d’Hebron University Hospital. She serves as a consultant in the Pediatric Pulmonology Department, where she treats complex respiratory conditions, including cystic fibrosis and bronchiectasis. Her clinical experience is complemented by her academic involvement as a lecturer in the Pediatric Pulmonology Master’s program at the Autonomous University of Barcelona. She completed international clinical training in Australia, focusing on bronchiectasis, and collaborates with research networks such as the ERS, ERN-Lung, and Child-BEAR-Net. Her career integrates hands-on patient care with data-driven research, highlighting her ability to translate science into practice. In leadership roles such as Chair of the ERS Task Force on adolescent bronchiectasis transition and Deputy Co-Chair of Child-BEAR-Net, she coordinates multinational teams and projects. Her balanced experience across clinical, research, and educational domains establishes her as a well-rounded and forward-thinking physician-scientist.

🏆 Awards and Honors

While specific individual awards are not listed in her profile, Dr. Laura Garriga-Grimau’s numerous prestigious roles and peer-reviewed publications serve as strong indicators of her academic and professional recognition. She has earned notable leadership positions in internationally recognized research bodies such as the European Respiratory Society (ERS) and the Child-BEAR-Net network, which are typically awarded based on merit, contribution, and peer endorsement. She is a key author and collaborator in top-tier journals including The Lancet Respiratory Medicine and The New England Journal of Medicine—an honor in itself that reflects a high level of expertise and scientific impact. Her inclusion in global studies and research registries, as well as her involvement in shaping clinical guidelines, affirms her reputation in the field of pediatric pulmonology. Furthermore, her appointment as faculty at a major academic institution and her PhD achievements represent high academic recognition within both national and international medical communities.

🔬Research Focus on Medicine and Dentistry

Dr. Garriga-Grimau’s research centers on pediatric bronchiectasis, cystic fibrosis, and related respiratory disorders, with an emphasis on improving diagnostics, treatment protocols, and health equity in chronic pediatric lung care. She is actively involved in several major international studies and registries, including the Child-BEAR-Net Registry and SHIP-CT trial. Her research evaluates multicountry clinical variations, healthcare transitions from adolescence to adulthood, and therapy optimization for children with chronic respiratory disease. She collaborates on translational studies that influence clinical guidelines and promote standardized care across different healthcare systems. Her work particularly emphasizes underserved populations, including Indigenous communities, reflecting her commitment to inclusive, global health research. By integrating clinical experience with robust epidemiological and translational approaches, Dr. Garriga-Grimau’s research not only advances scientific understanding but also directly enhances patient outcomes. She contributes to major publications and plays key roles in shaping pediatric pulmonology’s research priorities at the European and global level.

📚 Publications Top Notes

  • First results from the international paediatric bronchiectasis registry (Child‑BEAR‑Net Registry) describing multicountry variations in childhood bronchiectasis and its management: a multicentre, cross‑sectional study

    • Authors: Laura Garriga‑Grimau; Ahmad Kantar; Keith Grimwood; Charl Verwey; Refiloe Masekela; Diane Gray; Ameena Goga; Bulent Karadag; Ela Erdem Eralp; Yasemin Gokdemir; et al.

    • Year: 2025

    • Citations: 1 (as per Scopus/ResearchGate)

  • Guiding practice principles for clinicians who work with Indigenous people

    • Authors: André Schultz; Anne B. Chang; Donna M. Mason; Julie M. Marchant; Lesley A. Versteegh; Maree Toombs; Laura Garriga‑Grimau; CRE Extended Group

    • Year: 2025

  • Bronchiectasis in pediatrics

    • Authors: Laura Garriga‑Grimau; Eva Polverino; Antonio Moreno‑Galdó

    • Year: 2025

  • Implementation of the Spanish Paediatric Bronchiectasis Registry (Child‑BEAR‑es Registry)

    • Authors: Laura Garriga‑Grimau; Verónica Sanz‑Santiago; Antonio Moreno‑Galdó

    • Year: 2024

  • Improving the Diagnosis and Treatment of Paediatric Bronchiectasis Through Research and Translation

    • Authors: Anne B. Chang; Shyamali C. Dharmage; Julie M. Marchant; Gabrielle B. McCallum; Peter S. Morris; Andre Schultz; Maree Toombs; Danielle F. Wurzel; Stephanie T. Yerkovich; Keith Grimwood; Laura Garriga‑Grimau; CRE extended group

    • Year: 2024

  • Asma (book chapter)

    • Author: Laura Garriga‑Grimau

    • Year: 2022

  • Pneumònia per Streptococcus pyogenes a l’edat pediàtrica

    • Author: Laura Garriga‑Grimau

    • Year: 2022

  • The effect of inhaled hypertonic saline on lung structure in children aged 3–6 years with cystic fibrosis (SHIP‑CT)

    • Authors: Harm A.W.M. Tiddens; Yuxin Chen; Eleni‑Rosalina Andrinopoulou; et al., including Laura Garriga‑Grimau

    • Year: 2022

  • Triple Therapy for Cystic Fibrosis Phe508del‑Gating and ‑Residual Function Genotypes

    • Authors: Peter J. Barry; Marcus A. Mall; Antonio Álvarez; et al., including Laura Garriga‑Grimau

    • Year: 2021

  • How abnormal is the normal? Clinical characteristics of CF patients with normal FEV₁

    • Authors: Malena Cohen‑Cymberknoh; Elad Ben Meir; Silvia Gartner; et al., including Laura Garriga‑Grimau

    • Year: 2021

  • Earlier clinical case reports (2012–2015)

    • Authors: Laura Garriga‑Grimau et al.

    • Years: 2012–2015

📌 Conclusion

Dr. Laura Garriga-Grimau exemplifies the rare combination of clinical expertise, academic leadership, and collaborative spirit essential for advancing global pediatric pulmonology. Her commitment to research excellence, her leadership in multinational registries and task forces, and her drive to improve outcomes for children with chronic respiratory diseases mark her as an innovator in the field. Whether through her patient care, her mentorship of future specialists, or her groundbreaking studies in bronchiectasis and cystic fibrosis, Dr. Garriga-Grimau continues to push the boundaries of pediatric respiratory medicine. Her contributions resonate not only within academic journals but also in real-world clinical settings across borders. As she builds on her already distinguished career, she remains a key force in shaping the future of respiratory healthcare for children worldwide. Dr. Garriga-Grimau is undoubtedly a deserving candidate for any accolade recognizing research excellence, innovation, and global impact in medicine.

Mohamed Ahmed | Quality- medicine | Best Research Article Award

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Assist Prof Dr. Mohamed Ahmed | Quality- medicine | Best Research Article Award

Chair of qualit unit, College of engineering- KSU, Saudi Arabia

Dr. Mohamed Abdel Fattah Ahmed – Short Biography
🧑‍🏫 Dr. Mohamed Abdel Fattah Ahmed is a dedicated academic professional with an extensive career in engineering education. He currently serves as an Assistant Professor at King Saud University, College of Engineering, in Riyadh, Saudi Arabia, a position he has held since 1993. His earlier academic roles include teaching at Assiut University, Egypt, and part-time at Banah Higher Technological Institute. With over four decades of experience, Dr. Ahmed has made significant contributions to industrial engineering and mechanical engineering, specializing in quality management, decision-making, and project management. His broad expertise encompasses cost estimation, workshop design, and spare parts control.

Profile

Scopus

Strengths for the Award

Dr. Mohamed Abdel Fattah Ahmed demonstrates a robust academic and research background with a significant focus on engineering fields, particularly industrial and mechanical engineering. His extensive education, including a Ph.D. in Industrial Engineering from Japan, along with practical training in Total Quality Management (TQM), highlights his technical proficiency. The most notable strength is his recent contributions to the journal Mechanics of Advanced Materials and Structures in 2023. His research topics, including nonlinear continuum thermo-mechanics, advanced building materials, and artificial intelligence applications in engineering, show innovation, relevance, and interdisciplinary scope. These subjects are highly applicable to modern challenges in materials science, engineering, and artificial intelligence, marking his work as impactful and forward-thinking.

Areas for Improvement

While Dr. Mohamed’s research addresses contemporary issues, the language barrier might pose challenges, especially when writing and communicating complex ideas in English. His proficiency is described as “fair enough,” which may limit the clarity and accessibility of his publications. Additionally, while his research shows a high degree of specialization, expanding the practical applications of his findings or engaging in more collaborative, international research efforts could elevate his work’s influence and reach. Moreover, enhancing the focus on direct real-world implications, such as environmental or societal benefits, would strengthen the potential for wider recognition and impact in multidisciplinary contexts.

Education

🎓 Dr. Ahmed holds a Ph.D. in Industrial Engineering from Chubu University, Japan (1989), where he focused on quality engineering and service parts control. He also earned an M.Sc. in Mechanical Engineering from Assiut University, Egypt (1982), and a B.Sc. in Production Engineering from Alexandria University, Egypt (1976). Additionally, he holds a Diploma in Total Quality Management (TQM) from Kyoto University, Japan (1985). His further qualifications include certified Six Sigma Master Black Belt and PMP certification from PMI-USA.

Experience

🔧 Throughout his career, Dr. Ahmed has held various academic and professional positions, starting as a Teaching Assistant at Assiut University (1978-1983) and later as an Assistant Professor at the same institution (1990-1993). His long-standing tenure at King Saud University has allowed him to impart knowledge in industrial and production engineering, and he has been actively involved in various administrative and research roles. He is also an accredited Quality Management System Auditor (ISO 9001:2015).

Research Interests

🧠 Dr. Ahmed’s research interests span across several domains, including engineering management education, cost estimation, academic accreditation, decision-making processes, and quality management. He is particularly passionate about project management, workshop design, and spare parts control. His research contributes significantly to improving management systems and industrial processes.

Awards

🏆 Dr. Ahmed has received several certifications and professional recognitions, including being a Six Sigma Certified Master Black Belt (Integral-USA) and an IRCA Certified Quality Management System Auditor (ISO 9001:2015). His contributions to the academic and professional fields of engineering management have earned him respect and accolades throughout his career.

Publications Top Notes

📚 Dr. Ahmed has an impressive list of research publications, contributing to significant advancements in engineering and applied sciences. Below are some of his recent works:

“Robust Framework for Severity Detection of Knee Osteoarthritis Using an Efficient Deep Learning Model”, International Journal of Pattern Recognition and Artificial Intelligence, 2023. DOI: 10.1142/S0218001423520109

“Multi-Agent Variational Approach for Robotics: A Bio-Inspired Perspective”, Biomimetics, 2023. DOI: 10.3390/biomimetics8030294

“A Novel Evolving Framework for Energy Management in Combined Heat and Electricity Systems with Demand Response Programs”, Sustainability, 2023. DOI: 10.3390/su151310481

“Forced Vibration Analysis of the Axially Reinforced Thick Concrete Plate Using General Expression of the Polynomial Series Theory: Development and Validation of a Deep Neural Network”, Materials Today Communications, 2023. DOI: 10.1016/j.mtcomm.2023.106419

“Nonlinear Continuum Thermo-Mechanics of the Composite Thick Panel Used in Concrete Ceilings via General Expression of the Polynomial Series Theory”, Mechanics of Advanced Materials and Structures, 2023. DOI: 10.1080/15376494.2023.2218367

“Soft Computational Approach on the Thermoelastic Assessment of Sandwich Beams with Transversely Functionally Graded Composite Concrete Face-Sheets as an Advanced Building Material”, Mechanics of Advanced Materials and Structures, 2023. DOI: 10.1080/15376494.2023.2227413

Conclusion

Dr. Mohamed Abdel Fattah Ahmed is a strong candidate for the “Best Research Article Award” due to his substantial contributions to engineering and materials science. His innovative research in advanced materials, thermo-mechanics, and the integration of artificial intelligence aligns well with current global trends. However, improvement in communication skills and broader collaboration would further enhance the recognition of his work. Overall, his depth of knowledge and recent impactful publications make him a compelling contender for the award.

Yan Ni | Pharmaceutical Research | Best Researcher Award

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Dr. Yan Ni | Pharmaceutical Research | Best Researcher Award

Executive Director, Passage bio, United States

Profile

Google Scholar

Researcher Evaluation for “Best Researcher Award”

Strengths for the Award:

Extensive Expertise in Drug Development: Yan G. Ni, PhD, has over 15 years of experience in drug development, particularly in small molecules, biologics, and gene therapies. His work spans several critical therapeutic areas, including neurological and cardiovascular diseases, immune-oncology, hematology, and rare diseases. His contributions to IND/CTA submissions and regulatory interactions further highlight his deep involvement in the field.

Leadership in Translational Biomarker and Precision Medicine: Dr. Ni has demonstrated significant expertise in integrating preclinical and clinical biomarker strategies, contributing to the successful design and execution of biomarker-based clinical endpoints. His role in implementing PK and immunogenicity strategies across different phases of studies showcases his ability to bridge the gap between research and clinical application, a crucial factor in modern drug development.

Proven Management Skills: Dr. Ni’s management experience is evident in his ability to build and lead high-performing cross-functional teams. His leadership roles in international professional organizations like the AAPS and SAPA, as well as his track record of mentoring and inspiring others, underline his effectiveness as a leader in both scientific and organizational contexts.

High Scientific Productivity: With over 35 peer-reviewed publications, several book chapters, and six U.S. patents, Dr. Ni’s scientific output is substantial. His contributions to industry white papers and his role as an organizer and invited speaker at national and international conferences further affirm his thought leadership in the field.

Recognition and Awards: Dr. Ni has received numerous prestigious awards, such as the Passage Bio High Impact Award, Regeneron High Impact Award, AAPS Excellence in Ligand Binding Assays Award, and Merck Award of Excellence. These accolades reflect his high-impact contributions to the field and recognition by peers and industry leaders.

Areas for Improvement:

Broader Impact Beyond Specialized Fields: While Dr. Ni’s expertise is well-recognized within specialized areas such as biomarkers, precision medicine, and drug development, expanding his influence into broader, interdisciplinary research domains could enhance his candidacy for a “Best Researcher Award.” For example, engaging in research that impacts public health or other critical global issues might increase his visibility and impact.

Further Innovation in Emerging Therapeutic Areas: While Dr. Ni has made significant contributions to established therapeutic areas, greater involvement in cutting-edge fields such as artificial intelligence in drug discovery or personalized medicine could position him as a pioneer in these rapidly evolving areas.

Enhanced Collaboration with Global Initiatives: Although Dr. Ni has demonstrated leadership in professional organizations and consortia, expanding his collaborative efforts to include global health initiatives or large-scale, multi-national research projects could further amplify his contributions and align with broader global research priorities.

Professional Experience

Passage Bio, Philadelphia, PA
Executive Director, Biomarkers and Precision Medicine
2021-Present
Senior Director, Head of Biomarkers and Precision Medicine
2020-2021

Built and led a high-performing team responsible for driving clinical biomarker, PK/biodistribution, immunogenicity studies, and supporting clinical operations.

Developed and implemented biomarker, PK, and immunogenicity strategies to inform decision-making for neurodegenerative disease portfolios.

Led biomarker and precision medicine support for IND/CTA submissions and global regulatory interactions.

Oversaw partnerships with external CROs and laboratories, and collaborated with Clinical Study Teams on biomarker inclusion in clinical portfolios.

Regeneron, Tarrytown, NY
Associate Director, Precision Medicine, Early Clinical Development & Experimental Sciences
2016-2020

Designed and implemented biomarker strategies to support dose selection and efficacy readings for complement-mediated rare diseases.

Provided strategic leadership for discovery and early cardiovascular programs, influencing biomarker-driven decisions on target validation, disease indication selection, and patient stratification.

Led multiple biomarker-focused natural history studies with academic and clinical centers.

Bristol Myers Squibb, Princeton, NJ
Senior Research Investigator II, R&D/PD/ABD/BAS-Biologics
2012-2016

Supported biomarker bioanalytical strategy implementation for immuno-oncology, immunology, and cardiovascular diseases.

Supervised biomarker method development and validation by internal staff and CROs.

Provided strategic and technical input on biomarker bioanalytical plans, resources, and timelines for FIH and PoC studies.

Merck & Co., Inc., Rahway, NJ
Senior Research Scientist, Cardiovascular Franchise Atherosclerosis Group
2007-2011

Led the development of a 2nd generation fully human monoclonal antibody for PCSK9.

Established ELISA-based pharmacodynamics and target engagement biomarker assays.

University of Texas Southwestern Medical Center, Dallas, TX
Research Assistant Professor, Internal Medicine Department, Cardiology
2001-2007
Research Scientist, Department of Pharmacology & Alliance for Cellular Signaling
2001-2007

Conducted research on cardiac hypertrophy, heart failure, and aging, focusing on Akt and FOXO transcriptional factors.

Education and Training

Persuasive Leadership Development: Wharton Business School, University of Pennsylvania

Postdoctoral Training: Yale University, under Professors Gary Rudnick and Eric Nestler

Ph.D. in Neuroscience: University of California, Irvine, under Professor Ricardo Miledi

M.S. in Pharmacology: Institute of Basic Medical Sciences, Beijing, China

B.S. in Biochemistry: Anhui University, Hefei, China

Professional Honors

Passage Bio High Impact Award (2021)

Regeneron High Impact Award and Multiple STAR Awards (2016-2020)

AAPS Excellence in Ligand Binding Assays Award (2015)

BMS R&D ROC Award and Multiple STAR Awards (2014)

Merck Award of Excellence (2007, 2008, 2009)

Professional Affiliations

American Association of Pharmaceutical Scientists (AAPS):

Founding Member and Chair of the Biomarkers and Translational Medicine Community

Founding Member and Chair of the Gene and Cell Therapeutic Products Community

Sino-American Pharmaceutical Professionals Association (SAPA):

Director for Public Outreach and Executive Committee Member

Publications

Yang, J., Mapelli, C., Wang, Z., et al. (2022). An Optimized Agonist Peptide of Protease-activated Receptor 4 and its Use in a Platelet Aggregation Assay to Monitor the Pharmacodynamic Effects of PAR4 Antagonists. Platelets. DOI: 10.1080/09537104.2022.2053091

Hays, A., Amaravadi, L., Fernandez-Metzler, C., et al. (2022). Is Incurred Sample Reanalysis (ISR) applicable in Biomarker Assays? AAPS J, 24:65. DOI: 10.1208/s12248-022-00708-y

Ni, Y.G., King, L., Fernández-Metzler, C. (2022). Recent Progress in Biomarker Bioanalysis and Target Engagement in Bioanalytical Aspects in Biological Therapeutics. ISBN: 9781119523215. Edited by Xu, X. & Xu, W.

Conclusion:

Dr. Yan G. Ni, PhD, is an outstanding candidate for the “Best Researcher Award” based on his extensive contributions to drug development, biomarker research, and precision medicine. His leadership, scientific productivity, and recognition by peers make him a strong contender for the award. However, expanding his research impact into broader and more emerging fields could further strengthen his profile for this prestigious recognition.