Edio Maldonado | Biochemistry | Best Researcher Award

Dr. Edio Maldonado | Biochemistry | Best Researcher Award

Profesor, Universidad de Chile, Chile

👨‍🔬 Dr. Edio Luis Maldonado Maldonado is an accomplished biochemist and molecular biologist specializing in transcription regulation and molecular biology. Currently, he serves as an Associate Professor at the University of Chile, where he contributes to the Cellular and Molecular Biology Program. With a research background that spans several prestigious institutions, Dr. Maldonado is recognized for his pioneering work in RNA polymerase II transcription factors, with his research widely published in prominent scientific journals.

Publication Profile

Scopus

Education

🎓 Dr. Maldonado’s academic journey began with a Bachelor’s in Sciences from Universidad Austral de Chile (1979-1983). He then pursued a Master’s in Sciences with a focus on Immunology at the same university (1983-1987). To deepen his expertise, he completed his Ph.D. in Biochemistry and Molecular Biology at the University of Medicine and Dentistry of New Jersey (UMDNJ) in the USA (1990-1996).

Experience

🏛️ Dr. Maldonado has held notable academic and research positions throughout his career. He started as an Assistant Professor at the Universidad Austral de Chile (1984-1987). After completing his Ph.D., he undertook postdoctoral research at the Howard Hughes Medical Institute, UMDNJ (1996-1997). He then joined the University of Chile as an Assistant Professor (1997-2004) before advancing to his current role as an Associate Professor at the Faculty of Medicine in the Cellular and Molecular Biology Program.

Research Interests

🔬 Dr. Maldonado’s research primarily revolves around the molecular mechanisms of gene transcription in mammalian cells, focusing on the role of RNA polymerase II and its associated transcription factors. His work sheds light on transcriptional regulation, providing insights that could impact various fields, including genetics and disease pathology.

Awards

🏆 Dr. Maldonado’s contributions to molecular biology and biochemistry have earned him respect in the scientific community, with his research frequently cited by peers and featured in high-impact journals.

Publications

“Factors involved in specific transcription by mammalian RNA polymerase II: RNA polymerase II associating protein 30 is an essential component of transcription factor IIF.”
📖 Journal of Biological Chemistry (1988), 2, pp. 975-990.
[Cited by other researchers]

“Factors involved in specific transcription by mammalian RNA polymerase II: factors IIE and IIF independently interact with RNA polymerase II.”
📖 Journal of Biological Chemistry (1989), 264, pp. 8913-8921.
[Cited by other researchers]

“A TATA-like sequence located downstream of the transcriptional initiation site is required for expression of an RNA polymerase II transcribed gene.”
📖 Genes and Development (1990), 4, pp. 1611-1622.
[Cited by other researchers]

“Factors involved in specific transcription by mammalian RNA polymerase II: role of factors IIA, IID and IIB during formation of a transcription competent complex.”
📖 Molecular and Cell Biology (1990), 10, pp. 6335-6347.
[Cited by other researchers]

“Direct Interaction between adenovirus E1a protein and the TATA-box binding transcription factor IID.”
📖 Proceedings of the National Academy of Sciences USA (1991), 88, pp. 5124-5128.
[Cited by other researchers]

 

Magellan Tchouakui | Biochemistry | Young Scientist Award

 Dr. Magellan Tchouakui | Biochemistry | Young Scientist Award

Research scientist, Centre for Research in Infectious Diseases, Cameroon

🧬 Dr. Magellan Tchouakui is a Cameroonian research scientist at the Centre for Research in Infectious Diseases (CRID) and a Wellcome Trust Early-Career Fellow in Infection and Immunobiology at CRID/Liverpool School of Tropical Medicine (LSTM). Having completed his Ph.D. in 2020, he has authored over 40 peer-reviewed articles focusing on mosquito biology, insecticide resistance, and malaria transmission. His current research is supported by a prestigious Wellcome Trust Early Career Grant, running from 2024 to 2029, aimed at characterizing insecticide resistance-associated fitness costs in major African malaria vectors.

Profile

Google Scholar

Strengths for the Award

  1. Research Excellence and Innovation:
    • Dr. Tchouakui has made significant contributions to the field of medical entomology, particularly in understanding insecticide resistance in malaria vectors.
    • His work on the fitness cost of metabolic resistance to insecticides in African malaria vectors is pioneering and critical for malaria control strategies.
    • With over 40 peer-reviewed articles, he has a robust publication record in high-impact journals, showcasing the quality and impact of his research.
  2. Grants and Funding:
    • He has secured prestigious grants, such as the Wellcome Trust Early-Career Fellowship, demonstrating his ability to attract substantial research funding.
    • His role as PI and Co-PI in multiple projects funded by leading organizations (Wellcome Trust, CDC, Bayer, etc.) indicates strong leadership and project management skills.
  3. Professional Development and Contribution:
    • Dr. Tchouakui has been actively involved in various training programs and workshops, both as a participant and facilitator, indicating his commitment to continuous learning and knowledge dissemination.
    • His involvement in experimental trials for bed nets and indoor residual spraying products highlights his practical contributions to malaria control.
  4. Teaching and Mentorship:
    • He has experience lecturing in biostatistics, bacteriology, and mycology, and has been mentoring Ph.D. and Master’s students, demonstrating his dedication to educating the next generation of scientists.
  5. Recognition and Awards:
    • Numerous travel grants and invitations to present at international conferences underscore his recognition in the scientific community.
    • His role as a reviewer for several prestigious journals signifies his expertise and standing in the field.
  6. Professional Networks:
    • Membership in professional organizations such as ASTMH, PAMCA, and involvement in networks like VectorBiTE and AntiVec reflect his active engagement with the global research community.

Areas for Improvement

  1. Diversity of Research Focus:
    • While Dr. Tchouakui’s research on insecticide resistance is critical, broadening his research focus to include other aspects of vector control or related fields could enhance his contributions and impact.
  2. Collaborative Research:
    • Increasing collaborative efforts with researchers from different fields or regions may provide new insights and foster interdisciplinary approaches to malaria control.
  3. Public Engagement and Outreach:
    • Enhancing public engagement and science communication efforts can help translate research findings into policy and practice more effectively.
    • Participating in community outreach programs to educate the public about malaria prevention and control could amplify the societal impact of his work.
  4. Resource Allocation and Project Management:
    • Ensuring efficient allocation of resources and effective project management to maximize the outcomes of funded projects can further strengthen his research impact.

Education

🎓 Dr. Tchouakui holds a Ph.D. in Parasitology and Ecology from the University of Yaounde I (2020), where his thesis explored the fitness cost of metabolic resistance to insecticides in African malaria vectors. He also earned a Master of Science (MSc) in 2015 and a Bachelor of Science (BSc) in 2012 from the same university.

Experience

🔬 Dr. Tchouakui began his postdoctoral research at CRID under a Bill & Melinda Gates Foundation project, focusing on identifying markers of resistance to novel insecticides. He has extensive experience in mosquito biology, insecticide resistance monitoring, fitness cost evaluation, and malaria transmission studies. Additionally, he has facilitated numerous workshops and training sessions in molecular entomology and vector control.

Research Interest

🔍 Dr. Tchouakui’s research interests include studying the genetic and molecular mechanisms of insecticide resistance in malaria vectors, evaluating the efficacy of vector control tools, and investigating the fitness costs associated with resistance. He employs transcriptomic and genomic approaches to understand the drivers of resistance and collaborates on projects aimed at improving malaria vector management.

Awards

🏆 Dr. Tchouakui has received several travel grants to attend and present at international conferences, including the 3rd International Conference on Public Health in Africa (2023) and the 72nd Annual Meeting of the American Society of Tropical Medicine and Hygiene (2023). He is also a reviewer for multiple scientific journals.

Publications Top Notes

📚 Dr. Tchouakui has published numerous impactful research papers. Here are some of his key publications:

Cytochrome P450 metabolic resistance (CYP6P9a) to pyrethroids imposes a fitness cost in the major African malaria vector Anopheles funestus (Heredity, 2020) – Cited by 621

Combined over-expression of two cytochrome P450 genes exacerbates the fitness cost of pyrethroid resistance in the major African malaria vector Anopheles funestus (Pesticide Biochemistry and Physiology, 2021) – Cited by 632

A 6.5kb Intergenic Structural Variation Exacerbates the Fitness Cost of P450-Based Metabolic Resistance in the Major African Malaria Vector Anopheles funestus (Genes, 2022) – Cited by 626

Fitness Costs of the Glutathione S-Transferase Epsilon 2 (L119F-GSTe2) Mediated Metabolic Resistance to Insecticides in the Major African Malaria Vector Anopheles funestus (Genes, 2018) – Cited by 645

A marker of glutathione S-transferase-mediated resistance to insecticides is associated with higher Plasmodium infection in the African malaria vector Anopheles funestus (Scientific Reports, 2019) – Cited by 5772

Conclusion

Dr. Magellan Tchouakui is a highly accomplished researcher whose work has significantly advanced our understanding of insecticide resistance in malaria vectors. His extensive publication record, successful grant acquisitions, and active participation in professional development activities make him a strong candidate for the Best Researcher Award. While he could benefit from diversifying his research focus and enhancing public engagement, his current contributions and ongoing projects already demonstrate exceptional promise and impact in the field of medical entomology.

Anumesh Pathak | Biochemistry | Best Faculty Award

Dr. Anumesh Pathak | Biochemistry | Best Faculty Award

Senior Demonstrator, DR. RMLIMS, India

👨‍🔬 Dr. Anumesh K Pathak, a dedicated Ph.D. in Biochemistry, currently serves as a Senior Resident in the Department of Biochemistry at Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India. With a passion for molecular biology, he imparts knowledge to medical students, leading experiments and projects focusing on Alzheimer’s, T2DM, and kidney diseases. His expertise extends to executing in vivo studies, utilizing mouse and rat models. Proficient in various molecular and cell biology techniques, including DNA/RNA extraction, qPCR, Western Blot, immunohistochemistry, ELISA, Microarray, GC-MS/MS, and ICP-MS, Dr. Pathak actively contributes to advancing medical research. 🧪🔬

Profile

google scholar

researchgate

Experience

👨‍🔬 As a diligent Senior Resident in the Department of Biochemistry at Dr. Ram Manohar Lohia Institute of Medical Sciences since December 2023, I contribute significantly to molecular research. My role involves mentoring and conducting experiments for medical students, focusing on Alzheimer’s, T2DM, and kidney diseases. Previously, as an Applications Biochemist at the Central Research Laboratory (January 2022 – November 2023), I conducted impactful GC-MS/MS studies on pesticides and food additives. During my tenure as a Senior Research Fellow in the Department of Pathology (November 2018 – November 2021), I actively participated in research endeavors, ensuring lab safety and contributing to scientific publications. 🧪🔬

Education

🎓 Completing my Doctoral of Philosophy with a focus on the “Role of Glutathione S-transferase Genotypes in Signal Integration by GSTP1-JNK, and p53 Pathway in Non-Small Cell Lung Carcinoma” at the Department of Pathology, Dr. Ram Manohar Lohia Institute of Medical Sciences, in collaboration with BBD University, Lucknow (2015-2022), reflects my commitment to advanced medical research. My M.Sc. project at King George’s Medical University delved into an “Age-Dependent study of Aluminum Toxicity in Liver, Kidney, and Brain of male albino rats” (Feb. 2009 – June. 2009). Holding an M.Sc. in Biochemistry from B. U. University Bhopal and a B.Sc. in Chemistry and Botany from V. B. S. Purvanchal University Jaunpur(U.P.), I have consistently demonstrated academic excellence. 🧪🔬🎓

Research Focus

🔬 He research focuses on elucidating the intricate mechanisms underlying the synergistic effects of novel compounds in combating ovarian adenocarcinomas. The study, “Synergistic effect of piperine and paclitaxel on cell fate via cyt-c, Bax/Bcl-2-caspase-3 pathway in ovarian adenocarcinomas SKOV-3 cells” (European Journal of Pharmacology, 2016), explores the interplay of cyt-c, Bax/Bcl-2, and caspase-3 pathways. Additionally, my work extends to innovative therapeutic strategies, as demonstrated in “Synergistic effect of graphene oxide coated nanotised apigenin with paclitaxel (GO-NA/PTX): A ROS dependent mitochondrial mediated apoptosis in ovarian cancer” (Anti-Cancer Agents in Medicinal Chemistry, 2017). These studies contribute valuable insights into potential treatment modalities for ovarian cancer. 🔍🧪

Publications Top Notes

  1. “Synergistic effect of piperine and paclitaxel on cell fate via cyt-c, Bax/Bcl-2-caspase-3 pathway in ovarian adenocarcinomas SKOV-3 cells”
    • Authors: MK Pal, SP Jaiswar, AK Srivastav, S Goyal, A Dwivedi, A Verma, J Singh, …
    • Published in: European Journal of Pharmacology
    • Year: 2016
    • Link
    • Cited by: 57
  2. “Synergistic effect of graphene oxide coated nanotised apigenin with paclitaxel (GO-NA/PTX): A ROS dependent mitochondrial mediated apoptosis in ovarian cancer”
    • Authors: MK Pal, SP Jaiswar, A Dwivedi, S Goyal, VN Dwivedi, AK Pathak, …
    • Published in: Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal …
    • Year: 2017
    • Link
    • Cited by: 26
  3. “Lithium potentiate oxidative burden and reduced antioxidant status in different rat organs system”
    • Authors: DK Joshi, DS Chauhan, AK Pathak, S Mishra, M Choudhary, VP Singh, …
    • Published in: Int J Toxicol Pharmacol Res
    • Year: 2013
    • Link
    • Cited by: 9
  4. “Fluoride induces DNA damage and cytotoxicity in human hepatocellular carcinoma cells”
    • Authors: A Verma, D Ali, AK Pathak
    • Published in: Toxicological & Environmental Chemistry
    • Year: 2017
    • Link
    • Cited by: 8
  5. “Dynamic Changes in Circulatory Cytokines and Chemokines Levels in Mild to Severe COVID-19 Patients”
    • Authors: V Tiwari, J Agarwal, AK Pathak, S Singh
    • Published in: Indian Journal of Clinical Biochemistry
    • Year: 2023
    • Link
    • Cited by: 7