Jackline De Paula Ayres-Silva | radiation | Women Researcher Award Published on 21/08/202521/08/2025 by World Top Scientists Dr. Jackline De Paula Ayres-Silva | radiation | Women Researcher Award Senior Researcher at Oswaldo Cruz Foundation, Brazil Dr. Jackline de Paula Ayres-Silva is a dedicated researcher with expertise in hematopoiesis, oncology, and molecular biology, with training from leading institutions in Brazil and international research experience at the Mayo Clinic. Her work integrates classical molecular techniques with advanced genomic approaches, including array-CGH and whole exome sequencing, to investigate hematological malignancies and the progression of myeloproliferative neoplasms to acute leukemia. She has contributed to high-impact publications, mentored undergraduate students, and secured research grants, highlighting her leadership and commitment to advancing science. Her research spans diverse models such as mice, zebrafish, and human clinical studies, reflecting versatility and translational relevance. Recognized with several honors for outstanding scientific contributions and mentoring, she continues to strengthen her profile as both an independent investigator and collaborator in multidisciplinary teams. Dr. Ayres-Silva’s career demonstrates a balance of technical expertise, innovative research, and dedication to fostering future scientists. Professional Profile Google Scholar | Scopus Profile | ORCID Profile Education Dr. Jackline de Paula Ayres-Silva built a strong academic foundation through rigorous training in the biological and biomedical sciences. She earned her undergraduate degree in Biology/Genetics and went on to complete a master’s degree in Morphology, followed by a doctorate in Oncology at the National Cancer Institute in Brazil. Her academic journey included early research experiences as a scholarship recipient during her undergraduate studies and advanced training fellowships at prominent institutions, including the Mayo Clinic in the United States. These opportunities enabled her to gain exposure to diverse research methodologies, from traditional molecular biology techniques to state-of-the-art genomic approaches. Alongside her formal academic milestones, she pursued additional specialized training in histopathology, genomics, and cancer biology, equipping her with both theoretical knowledge and practical skills. This well-rounded education provided the necessary platform for her future contributions to cancer research, hematopoiesis, and molecular medicine. Experience Dr. Jackline de Paula Ayres-Silva has extensive research and professional experience across multiple scientific domains. Early in her career, she worked in the Anatomic Pathology Division at the Brazilian National Cancer Institute, where she assisted with histopathological diagnostics and research support. Her experience broadened internationally during a fellowship at the Mayo Clinic, where she was trained in advanced genomic methodologies under expert mentorship. Throughout her career, she has conducted research on both normal and pathological hematopoiesis using diverse models, including mice, zebrafish, and human patient samples. She has applied techniques ranging from PCR and immunohistochemistry to next-generation sequencing, enabling her to explore the genetic and molecular underpinnings of blood disorders and cancer progression. Beyond laboratory work, she has taken on roles as a mentor, guiding undergraduate students in research projects and fostering their academic growth. Her career demonstrates a balance of hands-on research expertise, academic mentorship, and international collaboration. Research Focus Dr. Jackline de Paula Ayres-Silva’s research is centered on understanding hematological malignancies, hematopoietic development, and the genetic mechanisms underlying disease progression. Her primary focus has been on myeloproliferative neoplasms and their evolution into acute leukemia, where she has contributed significantly to molecular diagnostics and monitoring. She has implemented and applied molecular assays for key mutations, including JAK2 and CALR, and worked on identifying genetic alterations linked to disease progression. Her research also extends to fetal hematopoietic development, exploring how the extracellular matrix and microenvironments influence blood cell formation. By integrating traditional pathology methods with high-throughput genomic tools such as whole exome sequencing and array-CGH, she has advanced knowledge in both basic and translational science. Additionally, her collaborative projects span chronic lymphocytic leukemia and central nervous system lymphomas, reflecting a broad interest in cancer genetics. Her ongoing work aims to model genetic alterations in vivo, further bridging laboratory discoveries with clinical relevance. Award and Honor Dr. Jackline de Paula Ayres-Silva has been recognized with several awards and honors that highlight her contributions to science, research mentorship, and academic excellence. Early in her career, she was acknowledged for her presentations at scientific congresses, being ranked among the top trainees at Fiocruz and receiving recognition for excellence in international symposiums on stem cell transplantation. Her achievements continued with distinctions such as best and third-best presentations at prestigious scientific meetings, reflecting both the quality and impact of her work. More recently, she received honorable mentions at the Annual Congress on Undergraduate Degree Fellowships organized by the Oswaldo Cruz Foundation, acknowledging her role in research mentorship and guidance. These honors not only demonstrate her capacity to produce significant scientific findings but also underline her dedication to fostering the next generation of researchers. Collectively, her awards validate her position as an accomplished and influential scientist in her field. Publication Top Notes Title: Genome-wide analysis uncovers novel recurrent alterations in primary central nervous system lymphomasAuthors: E. Braggio, S. Van Wier, J. Ojha, E. McPhail, Y.W. Asmann, J. Egan, J. Ayres-Silva, …Year: 2015Citations: 241 Title: Deep sequencing identifies genetic heterogeneity and recurrent convergent evolution in chronic lymphocytic leukemiaAuthors: J. Ojha, J. Ayres, C. Secreto, R. Tschumper, K. Rabe, D. Van Dyke, S. Slager, …Year: 2015Citations: 77 Title: Monoclonal B-cell lymphocytosis is characterized by mutations in CLL putative driver genes and clonal heterogeneity many years before disease progressionAuthors: J. Ojha, C. Secreto, K. Rabe, J. Ayres-Silva, R. Tschumper, D.V. Dyke, …Year: 2014Citations: 59 Title: Sequential morphological characteristics of murine fetal liver hematopoietic microenvironment in Swiss Webster miceAuthors: J. de Paula Ayres-Silva, P.P. de Abreu Manso, M.R. da Cunha Madeira, …Year: 2011Citations: 51 Title: Global profile of anemia during pregnancy versus country income overview: 19 years estimative (2000–2019)Authors: E. Araujo Costa, J. de Paula Ayres-SilvaYear: 2023Citations: 44 Title: Increased expression of tissue factor and protease-activated receptor-1 does not correlate with thrombosis in human lung adenocarcinomaAuthors: E. De Meis, D. Azambuja, J.P. Ayres-Silva, M. Zamboni, V.R. Pinheiro, …Year: 2010Citations: 34 Title: Lymphatic vessels in human adipose tissueAuthors: P.A.G. Redondo, F. Gubert, C. Zaverucha-do-Valle, T.P.P. Dutra, J. Ayres-Silva, …Year: 2020Citations: 26 Title: Hydroxyurea dose impacts hematologic parameters in polycythemia vera and essential thrombocythemia but does not appreciably affect JAK2-V617F allele burdenAuthors: I.R. Zalcberg, J. Ayres-Silva, A.M. de Azevedo, C. Solza, A. Daumas, …Year: 2011Citations: 17 Title: Genetic alterations in essential thrombocythemia progression to acute myeloid leukemia: a case series and review of the literatureAuthors: J.P. Ayres-Silva, M.H. Bonamino, M.E. Gouveia, B.C.R. Monte-Mor, …Year: 2018Citations: 12 Title: Clinical features of JAK2V617F- or CALR-mutated essential thrombocythemia and primary myelofibrosisAuthors: Z.I. Monte-Mor Bda C, J. de Paula Ayres-Silva, W.D. Correia, A.C. Coelho, C. Solza, …Year: 2016Citations: 12 Title: Oral Trypanosoma cruzi Acute Infection in Mice Targets Primary Lymphoid Organs and Triggers Extramedullary HematopoiesisAuthors: A. Marins-Dos-Santos, J.P. Ayres-Silva, D. Antunes, C.J.C. Moreira, …Year: 2022Citations: 6 Title: JAK2 V617F allele burden quantified by real time quantitative polymerase chain reaction and competitive polymerase chain reaction in patients with chronic myeloproliferative neoplasiaAuthors: J. Kaeda, M. Bonamino, J. Ayres-Silva, C. Solza, F. Ringel, O. Blau, …Year: 2014Citations: 4 Title: Lectin-based carbohydrate profile of megakaryocytes in murine fetal liver during developmentAuthors: B.C.M. Bomfim, J. Azevedo-Silva, G. Caminha, J.P.R. Santos, J. de Paula Ayres-Silva, …Year: 2023Citations: 3 Title: Animal welfare in radiation research: the importance of animal monitoring systemAuthors: M.R. Lima, D.C.P. Campbell, M.R. Cunha-Madeira, B.C.M. Bomfim, J. de Paula Ayres-Silva, …Year: 2023Citations: 2 Title: The genomic landscape of primary central nervous system lymphomasAuthors: E. Braggio, B.P. O’Neill, S. Van Wier, J. Ojha, J. Ayres-Silva, R. Valdez, J. Egan, …Year: 2013Citations: 2 Conclusion Dr. Jackline de Paula Ayres-Silva has established a solid body of research that spans hematology, oncology, molecular biology, and developmental biology, with impactful contributions recognized through both publications and citations. Her works range from fundamental studies on hematopoietic development to translational research on hematological malignancies, with particular emphasis on myeloproliferative neoplasms, leukemia, and cancer genomics. Several of her publications have been widely cited, underscoring their scientific influence and relevance in the research community. Beyond advancing knowledge, her collaborations with international institutions and contributions to multidisciplinary projects highlight her ability to work across diverse scientific environments. The combination of highly cited research, continuous output in peer-reviewed journals, and recognition in scientific forums positions her as a researcher of significant merit. Overall, Dr. Ayres-Silva demonstrates the expertise, innovation, and leadership qualities that strongly support her suitability for recognition such as the Best Researcher Award.
Dr. Jackline de Paula Ayres-Silva is a dedicated researcher with expertise in hematopoiesis, oncology, and molecular biology, with training from leading institutions in Brazil and international research experience at the Mayo Clinic. Her work integrates classical molecular techniques with advanced genomic approaches, including array-CGH and whole exome sequencing, to investigate hematological malignancies and the progression of myeloproliferative neoplasms to acute leukemia. She has contributed to high-impact publications, mentored undergraduate students, and secured research grants, highlighting her leadership and commitment to advancing science. Her research spans diverse models such as mice, zebrafish, and human clinical studies, reflecting versatility and translational relevance. Recognized with several honors for outstanding scientific contributions and mentoring, she continues to strengthen her profile as both an independent investigator and collaborator in multidisciplinary teams. Dr. Ayres-Silva’s career demonstrates a balance of technical expertise, innovative research, and dedication to fostering future scientists. Professional Profile Google Scholar | Scopus Profile | ORCID Profile Education Dr. Jackline de Paula Ayres-Silva built a strong academic foundation through rigorous training in the biological and biomedical sciences. She earned her undergraduate degree in Biology/Genetics and went on to complete a master’s degree in Morphology, followed by a doctorate in Oncology at the National Cancer Institute in Brazil. Her academic journey included early research experiences as a scholarship recipient during her undergraduate studies and advanced training fellowships at prominent institutions, including the Mayo Clinic in the United States. These opportunities enabled her to gain exposure to diverse research methodologies, from traditional molecular biology techniques to state-of-the-art genomic approaches. Alongside her formal academic milestones, she pursued additional specialized training in histopathology, genomics, and cancer biology, equipping her with both theoretical knowledge and practical skills. This well-rounded education provided the necessary platform for her future contributions to cancer research, hematopoiesis, and molecular medicine. Experience Dr. Jackline de Paula Ayres-Silva has extensive research and professional experience across multiple scientific domains. Early in her career, she worked in the Anatomic Pathology Division at the Brazilian National Cancer Institute, where she assisted with histopathological diagnostics and research support. Her experience broadened internationally during a fellowship at the Mayo Clinic, where she was trained in advanced genomic methodologies under expert mentorship. Throughout her career, she has conducted research on both normal and pathological hematopoiesis using diverse models, including mice, zebrafish, and human patient samples. She has applied techniques ranging from PCR and immunohistochemistry to next-generation sequencing, enabling her to explore the genetic and molecular underpinnings of blood disorders and cancer progression. Beyond laboratory work, she has taken on roles as a mentor, guiding undergraduate students in research projects and fostering their academic growth. Her career demonstrates a balance of hands-on research expertise, academic mentorship, and international collaboration. Research Focus Dr. Jackline de Paula Ayres-Silva’s research is centered on understanding hematological malignancies, hematopoietic development, and the genetic mechanisms underlying disease progression. Her primary focus has been on myeloproliferative neoplasms and their evolution into acute leukemia, where she has contributed significantly to molecular diagnostics and monitoring. She has implemented and applied molecular assays for key mutations, including JAK2 and CALR, and worked on identifying genetic alterations linked to disease progression. Her research also extends to fetal hematopoietic development, exploring how the extracellular matrix and microenvironments influence blood cell formation. By integrating traditional pathology methods with high-throughput genomic tools such as whole exome sequencing and array-CGH, she has advanced knowledge in both basic and translational science. Additionally, her collaborative projects span chronic lymphocytic leukemia and central nervous system lymphomas, reflecting a broad interest in cancer genetics. Her ongoing work aims to model genetic alterations in vivo, further bridging laboratory discoveries with clinical relevance. Award and Honor Dr. Jackline de Paula Ayres-Silva has been recognized with several awards and honors that highlight her contributions to science, research mentorship, and academic excellence. Early in her career, she was acknowledged for her presentations at scientific congresses, being ranked among the top trainees at Fiocruz and receiving recognition for excellence in international symposiums on stem cell transplantation. Her achievements continued with distinctions such as best and third-best presentations at prestigious scientific meetings, reflecting both the quality and impact of her work. More recently, she received honorable mentions at the Annual Congress on Undergraduate Degree Fellowships organized by the Oswaldo Cruz Foundation, acknowledging her role in research mentorship and guidance. These honors not only demonstrate her capacity to produce significant scientific findings but also underline her dedication to fostering the next generation of researchers. Collectively, her awards validate her position as an accomplished and influential scientist in her field. Publication Top Notes Title: Genome-wide analysis uncovers novel recurrent alterations in primary central nervous system lymphomasAuthors: E. Braggio, S. Van Wier, J. Ojha, E. McPhail, Y.W. Asmann, J. Egan, J. Ayres-Silva, …Year: 2015Citations: 241 Title: Deep sequencing identifies genetic heterogeneity and recurrent convergent evolution in chronic lymphocytic leukemiaAuthors: J. Ojha, J. Ayres, C. Secreto, R. Tschumper, K. Rabe, D. Van Dyke, S. Slager, …Year: 2015Citations: 77 Title: Monoclonal B-cell lymphocytosis is characterized by mutations in CLL putative driver genes and clonal heterogeneity many years before disease progressionAuthors: J. Ojha, C. Secreto, K. Rabe, J. Ayres-Silva, R. Tschumper, D.V. Dyke, …Year: 2014Citations: 59 Title: Sequential morphological characteristics of murine fetal liver hematopoietic microenvironment in Swiss Webster miceAuthors: J. de Paula Ayres-Silva, P.P. de Abreu Manso, M.R. da Cunha Madeira, …Year: 2011Citations: 51 Title: Global profile of anemia during pregnancy versus country income overview: 19 years estimative (2000–2019)Authors: E. Araujo Costa, J. de Paula Ayres-SilvaYear: 2023Citations: 44 Title: Increased expression of tissue factor and protease-activated receptor-1 does not correlate with thrombosis in human lung adenocarcinomaAuthors: E. De Meis, D. Azambuja, J.P. Ayres-Silva, M. Zamboni, V.R. Pinheiro, …Year: 2010Citations: 34 Title: Lymphatic vessels in human adipose tissueAuthors: P.A.G. Redondo, F. Gubert, C. Zaverucha-do-Valle, T.P.P. Dutra, J. Ayres-Silva, …Year: 2020Citations: 26 Title: Hydroxyurea dose impacts hematologic parameters in polycythemia vera and essential thrombocythemia but does not appreciably affect JAK2-V617F allele burdenAuthors: I.R. Zalcberg, J. Ayres-Silva, A.M. de Azevedo, C. Solza, A. Daumas, …Year: 2011Citations: 17 Title: Genetic alterations in essential thrombocythemia progression to acute myeloid leukemia: a case series and review of the literatureAuthors: J.P. Ayres-Silva, M.H. Bonamino, M.E. Gouveia, B.C.R. Monte-Mor, …Year: 2018Citations: 12 Title: Clinical features of JAK2V617F- or CALR-mutated essential thrombocythemia and primary myelofibrosisAuthors: Z.I. Monte-Mor Bda C, J. de Paula Ayres-Silva, W.D. Correia, A.C. Coelho, C. Solza, …Year: 2016Citations: 12 Title: Oral Trypanosoma cruzi Acute Infection in Mice Targets Primary Lymphoid Organs and Triggers Extramedullary HematopoiesisAuthors: A. Marins-Dos-Santos, J.P. Ayres-Silva, D. Antunes, C.J.C. Moreira, …Year: 2022Citations: 6 Title: JAK2 V617F allele burden quantified by real time quantitative polymerase chain reaction and competitive polymerase chain reaction in patients with chronic myeloproliferative neoplasiaAuthors: J. Kaeda, M. Bonamino, J. Ayres-Silva, C. Solza, F. Ringel, O. Blau, …Year: 2014Citations: 4 Title: Lectin-based carbohydrate profile of megakaryocytes in murine fetal liver during developmentAuthors: B.C.M. Bomfim, J. Azevedo-Silva, G. Caminha, J.P.R. Santos, J. de Paula Ayres-Silva, …Year: 2023Citations: 3 Title: Animal welfare in radiation research: the importance of animal monitoring systemAuthors: M.R. Lima, D.C.P. Campbell, M.R. Cunha-Madeira, B.C.M. Bomfim, J. de Paula Ayres-Silva, …Year: 2023Citations: 2 Title: The genomic landscape of primary central nervous system lymphomasAuthors: E. Braggio, B.P. O’Neill, S. Van Wier, J. Ojha, J. Ayres-Silva, R. Valdez, J. Egan, …Year: 2013Citations: 2 Conclusion Dr. Jackline de Paula Ayres-Silva has established a solid body of research that spans hematology, oncology, molecular biology, and developmental biology, with impactful contributions recognized through both publications and citations. Her works range from fundamental studies on hematopoietic development to translational research on hematological malignancies, with particular emphasis on myeloproliferative neoplasms, leukemia, and cancer genomics. Several of her publications have been widely cited, underscoring their scientific influence and relevance in the research community. Beyond advancing knowledge, her collaborations with international institutions and contributions to multidisciplinary projects highlight her ability to work across diverse scientific environments. The combination of highly cited research, continuous output in peer-reviewed journals, and recognition in scientific forums positions her as a researcher of significant merit. Overall, Dr. Ayres-Silva demonstrates the expertise, innovation, and leadership qualities that strongly support her suitability for recognition such as the Best Researcher Award.
Dr. Jackline de Paula Ayres-Silva has established a solid body of research that spans hematology, oncology, molecular biology, and developmental biology, with impactful contributions recognized through both publications and citations. Her works range from fundamental studies on hematopoietic development to translational research on hematological malignancies, with particular emphasis on myeloproliferative neoplasms, leukemia, and cancer genomics. Several of her publications have been widely cited, underscoring their scientific influence and relevance in the research community. Beyond advancing knowledge, her collaborations with international institutions and contributions to multidisciplinary projects highlight her ability to work across diverse scientific environments. The combination of highly cited research, continuous output in peer-reviewed journals, and recognition in scientific forums positions her as a researcher of significant merit. Overall, Dr. Ayres-Silva demonstrates the expertise, innovation, and leadership qualities that strongly support her suitability for recognition such as the Best Researcher Award.